BREVETTI / PATENTS

  1. PROCESS FOR THE PREPARATION OF RALTEGRAVIR. Piccolo, O. , (Cambrex Profarmaco S.r.l) WO 2019096773(2019).

  1. BIOLOGICALLY ACTIVE FORMULATION. Piccolo, O. , Borzatta, V., Delogu, G., Capparella, E., De Candia, C., Gobbi, C., Di Blasi, G., (Endura S.P.A) US10149478 (2018).

  1. BIOLOGICALLY ACTIVE FORMULATION. Piccolo, O. , Borzatta, V., Delogu, G., Capparella, E., De Candia, C., Gobbi, C., Di Blasi, G., (Endura S.P.A.) US 9775340 (2017).

  1. PROCESS FOR THE PREPARATION OF 2-(3-N,N-DIISOPROPYLAMINO-1-PHENYLPROPYL)-4-HYDROXYMETHYL-PHENOL AND ITS DERIVATIVES. Piccolo, O. , Giannini, E., Bigini, L., Gianolli, E., Vigo, D., (Cambrex Profarmaco S.r.l) WO 2014012832 (2014)..

  1. NEW AMINOACID DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS INHIBITORS OF ONCOGENIC SIGNALS BY THE MET FAMILY. , Maina, F., Dono, R., Cambillau, C., Piccolo, O. , Passarella, D., Colombo, F., Bosch, J., Maigret, B., Laroux, V., (Universitè de Marseille et al.). US 8822698 (2014).

  1. PROCESS FOR THE PREPARATION OF N,N-DIISOPROPYL-3-(2-HYDROXY-5-METHYLPHENYL)-3-PHENYL PROPYLAMINE AND ITS SALTS STARTING FROM A NOVEL INTERMEDIATE. , Gianolli, E., Giannini, E., Bigini, L., Piccolo, O. , Holmberg, P., Lundholm, T. ( Cambrex Profarmaco S.r.l.) WO 2012098044 (2012).

  1. PROCEDIMENTO PER LA PREPARAZIONE DI (R) TOLTERODINA (L) TARTRATO DI FORMA CRISTALLINA DEFINITA. , Gianolli, E., Giannini, E., Bigini, L, Piccolo, O. , (Cambrex Profarmaco S.r.l.) IT MI2011A000410 (2012).

  1. INSECTICIDE FORMULATION. Piccolo, O. , Delogu, G., Borzatta, V., (Endura S.P.A.). US8337871 (2012)

  1. INNOVATIVE FORMULATION. , Borzatta, V., Piccolo, O. , Capparella, E., (Endura S.P.A.). US8025894 (2011).

  1. A PROCESS FOR THE PURIFICATION OF PHOSPHATIDYLSERINE. , De Ferra, L., Massardo, P., Piccolo, O. , Servi, S., (Chemi S. p. A.) EP 922707 (2009)

  1. SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS FOR THE PARENTERAL ADMINISTRATION OF BIOLOGICALLY ACTIVE HYDROPHILIC COMPOUNDS. , Autuori, F., Bianchini, C., Leoni, F., Mascagni, P., Monzani, W., Piccolo, O. , Bottoni, G., (Italfarmaco S.p.A.) US 7157099 (2007).

  1. METAL COMPLEX CATALYSTS FOR CHEMO-, REGIO- AND STEREOSELECTIVE REACTIONS, AND CORRESPONDING PRECURSORS , Sannicolò, F., Piccolo, O. , Benincori, T., Sada, M., Verrazzani, A., Tollis, S., Ullucci, E., De Ferra, L., Rizzo, S., (Chemi S.p.A.) US 7307037 (2007).

  1. PROCESS OF RESOLUTION OF A CARNITINAMIDE SALT. , Pallavicini, M., Bolchi, C., Fumagalli, L., Piccolo, O. , Valoti, E., (Università di Milano & Piccolo Oreste) EP 1852416 (2007).

  1. ENANTIOSELECTIVE SYNTHESIS OF ENANTIOMERICALLY ENRICHED COMPOUNDS.Piccolo, O. , Ulgheri, F., Marchetti, M., (Piccolo Oreste & Consiglio Nazionale delle Ricerche, Italy). EP 1644311 (2006).

  1. PROCESS FOR PREPARING ALKOXY- AND ARYLOXY-PHENOLS , Borzatta, V., Piccolo, O. , Capparella, E., Poluzzi, E., (Endura S.P.A.) WO 2004092106 (2004).

  1. PREPARATION AND USE OF A HETEROGENEOUS CATALYST FOR THE HYDROGENATION OF A DOUBLE BOND OF AN ALPHA, BETA–UNSATURATED CARBONYL COMPOUND. Piccolo, O. , Verrazzani, A., (Chemi S.p.A.) US 7087548 (2006).

  1. PROCESS FOR THE PREPARATION OF (R)- OR (S)-AMINOCARNITINE INNER SALT AND THEIR SALTS AND DERIVATIVES. Piccolo, O. , Castagnani, R., De Witt Scalfaro, P., (Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.) US 6953865 (2005).

  1. STEREOSPECIFIC ACID HYDROLYSIS OF OPTICALLY ACTIVE ESTERS.Piccolo, O. , Castagnani, R., De Witt, Scalfaro P., (Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.) US 6593478 (2003).

  1. CHIRAL PHOSPHORATED LIGANDS USEFUL IN CATALYSTS.Piccolo, O. , Gancia, E., Zaliani, A., Bonifacio, F., (Chemi S.p.A.) EP 1070075 (2003).

  1. INDUSTRIAL PROCESS FOR THE PRODUCTION OF L-CARNITINE. , Tinti, M. O., Piccolo, O. , Bonifacio, F., Crescenzi, C., Penco, S., (Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.) US 6566552 (2003)

  1. NITRILOXY DERIVATIVES OF (R) AND (S)-CARNITINE Piccolo, O. , ., Castagnani, R., De Witt Scalfaro, P., (Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.) US 6548693 (2003).

  1. NITRILOXY DERIVATIVES OF (R) AND (S)-CARNITINE.Piccolo, O. , Castagnani, R., De Witt, Scalfaro P., (Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.) US 6395923 (2002).

  1. PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED 4-PHENYL-PIPERIDINE DERIVATIVE. , De Ferra, L., Massardo, P., Piccolo, O. , Cignarella, G., (Chemi S.p.A.) US 6444822 (2002).

  1. PROCEDIMENTO PER PREPARARE COMPOSTI INDOLICI. , Campanati, M., Piccolo, O. , Vaccari, A., Massardo, P., (Chemi S.p.A.) Ital. 1303260 (2000).

  1. PREPARATION OF (±)-2-[4-(2-OXOCYCLOPENTYLMETHYL)PHENYL] PROPIONIC ACID AND THEIR SALTS AS ANTIINFLAMMATORY DRUGS. Piccolo, O. , Massardo, P., De Ferra, L., D'Amico, F., (Chemi S. p. A.). JP 3009860 (2000).

  1. A PROCESS FOR THE INDUSTRIAL PREPARATION OF PHOSPHATIDYL SERINE. , De Ferra, L., Massardo, P.,Piccolo, O. , Servi, S., (Italfarmaco Sud S.p.A.) US 5700668 (1997).

  1. PROCESS FOR THE PREPARATION OF PHOSPHORIC DIESTERS. , Bonifacio, F., De Ferra, L.,Piccolo, O. , Turchetta,S.,(Italfarmaco Sud S.p.A.) Ital. 1264941 (1996).

  1. SEPARATION OF DEACYLATED GLYCEROPHOSPHOLIPID MIXTURES BY ELECTRODIALYSIS. De Ferra, L., Rondinini, S., Mussini, P. R., Bonifacio, F., Massardo, Piccolo, O. , (Chemi S.p.A.) US 54338333 (1995).

  1. SYNTHESIS OF (R)- AND (S)-ALKYLIDENEGLYCEROL. Piccolo, O. , Pallavicini, M., Valoti,E.,Villa, L., (Piccolo Oreste & Università di Milano) Ital. 1254201(1995).

  1. PROCEDIMENTO PER LA PREPARAZIONE DI FOSFATIDI. Bonifacio, F., De Ferra., L., Piccolo, O. , Turchetta, S., (Chemi S.p.A.) Ital 1250730 (1995)

  1. A PROCESS FOR THE PREPARATION OF GLYCEROPHOSPHOLIPIDS. De Ferra, L., Bonifacio, F., Cifarelli, G., Massardo, P., Piccolo, O. , (Chemi S.p.A.). US 5315023 (1994).

  1. NEW ELECTROCHEMICAL PROCESS FOR THE PREPARATION OF ANTIINFLAMMATORY 2-ARYLPROPIONIC ACIDS.Maspero, F., Piccolo, O. , Romano, U., Gambino, S., (Enichem Sintesi S.p.A.). US 5089661 (1992).

  1. PREPARATION OF 7β-HYDROXY-SUBSTITUTED BILE ACIDS BY STEREO- SELECTIVE HYDROGENATION OF THE 7-KETO GROUP IN BILE KETO ACIDS USING NICKEL CATALYSTS. Magni, A., Piccolo, O. , Ascheri, A., (Blaschim S.p.A.). US 4834919 (1989).

  1. PROCESS FOR PREPARING NAPROXEN.Piccolo, O. , Valoti, E., Visentin, G., (Blaschim S.p.A) US 4864063 (1989).

  1. 2(3H)-BENZOFURAN AND DERIVATIVES. Piccolo, O. , Citterio, A., Valoti, E., (Blaschim S.p.A.) Ital. 1191142(1988).

  1. ARYL-ALKOXY-IODO-ETHANE CARBONYL DERIVATIVES . Giordano, C., Citterio, A.,Piccolo, O. , Gandolfi, M., (Blaschim S.p.A. & Consiglio Nazionale delle Ricerche) Ital. 1190867 (1988).

  1. RESOLUTION OF (±) 2[2-(P-FLUOROPHENYL)-5-BENZOXAZOLYL]-PROPIONIC ACID. Verga, A., Valoti, E., Piccolo, O. (Ravizza S.p.A.). US 4698432 (1987).

  1. ARYL ALKYL KETONES. Piccolo, O. , Visentin, G., Blasina, P., Spreafico, F., (Blaschim S.p.A.). US 4670603 (1987).

  1. PROCESS FOR PREPARING (O-HYDROXYARYL)-METHANOLS. Citterio, A., Tinucci, L., Piccolo, O. , Valoti, E., Filippini, L., Gandolfi, M., (Blaschim S.p.A. & Consiglio Nazionale delle Ricerche). EP 0098012(1986).

  1. PROCESSO PER LA ACILAZIONE E ALCHILAZIONE CATALITICA DI COMPOSTI AROMATICI E ETERO-AROMATICI. Casagrande,F.,Piccolo, O. , Martinengo, T., (Montedison S.p.A.) Ital. 1140316 (1986).

  1. PROCESS FOR THE OPTICAL RESOLUTION OF (±)-2-(6-METHOXY-2-NAPHTHYL)-PROPIONIC ACID. Piccolo, O. , Villa, G., Zen, E., (Blaschim S.p.A.) US 4546201 (1985).

  1. PROCESS FOR PREPARING BIARYL COMPOUNDS VIA COUPLING OF AN ARYLAMINE WITH AN ARENE. Belli, A., Citterio, A., Piccolo, O. , Villa, G., Zen, E., (Blaschim S.p.A.). US 4542233 (1985).